Based on the qualitative screening test, the crude extract of combretum molle was found to be positive for the presence of alkaloids, anthraquinone, terpenoids, flavonoids, and phenols, which have been considered to have antiplasmodial activity. The density of the secretory scales is higher on the abaxial leaf surface in the intervein areas. The name combretum was given by pliny to a particular climbing plant, the identity of which has been lost in time. Ethanol was used as solvent for extraction, after which differential fractionization was carried out using distilled water, ethyl acetate and. Combretum molle occurs widely in africa and is used traditionally to treat many different ailments including microbial infections. It is recorded to contain antioxidants such as punicalagin, which is also found in the other myrtale pomegranates punica granatum, a somewhat related plant. Inhibition of hematopoietic prostaglandin d2 synthase hpgds. Combretum molle is widespread and not in danger of genetic erosion, but in regions where population pressure is high, the wood is overexploitation for fuel wood. Different combretum molle combretaceae leaf extracts. Evaluation of antimalarial activity of the 80% methanolic.
Research article open access inhibition of hematopoietic prostaglandin d 2 synthase hpgds by an alkaloid extract from combretum molle rejoice moyo1, theresa chimponda2 and stanley mukanganyama2,3 abstract background. This work was carried out with the aim of determining the acute toxicity and histology of the aqueous, nbutanol and the ethylacetate fractions of the leaves of combretum molle to wistar rats. Chronic oral safety study of the aqueous extract of combretum. Research article open access antibacterial and antibiotic. Antibacterial and antifungal activities of extracts of combretum molle. The chemical profile of the plant is well characterized, and the isolation studies were done on extracts prepared from the stem bark or leaves. Antibacterial and antifungal activities of extracts of combretum molle article pdf available in ethiopian medical journal 443. Combretum molle combretaceae is widely used traditional medicinal plant for treatment of different illnesses in most parts of africa. Inhibition of hematopoietic prostaglandin d 2 synthase hpgds by an alkaloid extract from combretum molle rejoice moyo, 1 theresa chimponda, 2 and stanley mukanganyama 2, 3 1 school of pharmacy, college of health sciences, university of zimbabwe, mt. Effect of combretum molle combretaceae seed extract on.
This article is from cardiovascular journal of africa, volume 19. More than 60 medical indications were reported for the use of these plants in traditional. Pdf effect of combretum molle combretaceae seed extract on. Plant groups and tree species relationship in a miombo. Combretum molle is a small to medium, quick growing deciduous tree that will attract birds as well. Each secretory scale is made up of a basal epidermal cell, a short bicellular stalk and a. Don is a mediumsized tree that is common throughout south africa. The aim of the present study was to evaluate the effects of aqueous extract from c. Access is allocated within two business days of purchase and lasts one year. Young plants need protection from the cold in winter but.
The cardiovascular effects of mollic acid glucoside mag, a. A web site containing information about the flora of botswana. The immature leaves of combretum molle have fine, soft hairs giving the leaves a velvety feel. All of the plant extracts combretum molle leaves and fruit, euclea crispa. This article appeared in a journal published by elsevier. Combretum molle has been used in many traditional medicines for treatment of microbial infections diarrhea, dysentery, fever and several inflammatory conditions abdominal pain, headache, and toothache. It is also frequently cut down on agricultural land, and this can lead to its local disappearance. Ethnopharmacological survey of six medicinal plants from mali. Julbernardia globiflora woodland, combretum molle sclerocarya birrea combretum zeyheriiacacia seyal var fistula woodland, bridelia catharticadiospyros mespiliformis woodland, brachystegia busseipterocarpus tinctorius woodland and brachystegia microphyllaisoberlinia tomentosahymenocardia acida syzygium owariense woodland. Cardiovascular effects of mollic acid glucoside, a 1. The plants investigated were biopyhtum petersianum, cola cordifolia, combretum molle, opilia celtidifolia, parkia biglobosa and ximenia americana. Combretum molle is an extremely variable shrub or small tree, usually growing 3 10 metres tall, but occasionally to 16 metres. In vitro antimicrobial activity of combretum molle. View of therapeutic evaluation of combretum molle combretaceae.
This paper reports the results of a study on the morphology, mode of secretion, ultrastructure and histochemistry of leaf secretory scales of combretum molle using both light and electron microscopy. Combretum, the bushwillows or combretums, make up the type genus of the family combretaceae. The activities of the aqueous crude extracts of the leaf. Combretum molle is widely used as a medicinal plant in rural communities. Dec 30, 2011 following the rapidly expanding dairy enterprise, mastitis has remained the most economically damaging disease. Don combretaceae is distributed especially in tropical africa and used in treatment various diseases including diabetes. Permission is granted to copy, distribute andor modify this document under the terms of the gnu free documentation licensegnu free documentation license. Therapeutic evaluation of combretum molle combretaceae bush willow stembark extract in experimental avian coccidiosis download download pdf. Dried ground leaves were extracted with methanol, butanol, acetone, ethyl acetate, chloroform, dichloromethane and nhexane. The leaf secretory scales of combretum molle combretaceae morphology, ultrastructure and histochemistry. Combretum molle leaves, have been investigated in mice and rats 81.
Click on each image to see a larger version and details of the record view all images 17 photo. However, its in vivo toxic effect is not evaluated yet. Some work has been done on the antimicrobial activity of bark extracts, but not on leaf extracts, a sustainable resource. Inhibition of hematopoietic prostaglandin d 2 synthase h. Aqueous extract of combretum molle boughs ameliorates. Diels combretaceae against antibioticresistant and susceptible staphylococcus aureus and streptococcus agalactiae isolated. Media in category combretum molle the following 11 files are in this category, out of 11 total. Therefore, further fractionation and characterization of the crude extract is necessary to identify the responsible lead compounds responsible for antiplasmodial activity. It is evergreen where there is sufficient moisture, but can become deciduous in. Toxicological and histological studies of the ethyl acetate.
Don combretaceae is a graceful deciduous shrub, distributed especially in tropical africa and used in traditional medicine in the treatment of. Therefore it did not qualify for the categories critically endangered, endangered, vulnerable or near vulnerable when it was evaluated. Animals were divided into 5 groups and treated for 30 days. Research article open access inhibition of hematopoietic. The genus comprises about 370 species of trees and shrubs, roughly 300 of which are native to tropical and southern africa, about 5 to madagascar, some 25 to tropical asia and approximately 40 to tropical america. Seven flavonoids with antibacterial activity isolated from combretum. This work was carried out with the aim of determining the phytochemical compounds present in the methanol extracts of the leaves. Pdf antibacterial and antifungal activities of extracts. Combretum molle tree africaugandabusinesstravelguide. Department of agriculture agricultural research service.
Velvet bushwillow e basterrooibos a umbondwe z native to southern africa tree tree no 537. Dec 27, 2008 an ethnopharmacological survey was carried out to collect information about the use of six medicinal plants in the regions around siby and dioila, mali. The leaf secretory scales of combretum molle combretaceae. The results can also be downloaded as a csv file unicode utf8 encoding see status, confidence level, source for definitions. Hematopoietic prostaglandin d 2 synthase hpgds, gst sigma is a member of the glutathione. As a standard protocol, initially the acute toxicity of the plant seed extract was checked following single administration of crude seed extract of the plant at doses 500, and 2000 mgkg. Combretum molle in the germplasm resources information network grin, u. The attached copy is furnished to the author for internal noncommercial research and education use, including for instruction at the authors institution and sharing with colleagues.
Atcc xtt cell proliferation assay kit instruction manual, 2011. The findings of the present study has supported the folklore use of the leaves of combretum molle in the treatment of malaria. Pdf the effect of combretum molle seed extracts on the. Objective of the study was to evaluate in vivo antiplasmodial activities of combretum molle seed extract methods. Efflux pumps, extracts, gramnegative bacteria, mdr bacteria, resistance modulators background infectious diseases caused by multidrug resistant mdr. Combretum molle plantinfo everything and anything about. Combretum molle will attract bees and other insects with its sweet sent. Antibacterial and antibiotic resistance modifying activity of the extracts from allanblackia gabonensis, combretum molle and gladiolus quartinianus against gramnegative bacteria including multidrug resistant phenotypes. Antibacterial and antibiotic resistance modifying activity of. It is evergreen where there is sufficient moisture, but can become deciduous in dry seasons.
The enzyme catalyses the conversion of pgh2 to pgd2 which mediates inflammatory responses. Don were harvested in ngassa, a small village about a few kilometres from mindif, in the farnorth region of cameroon. Pdf the leaf secretory scales of combretum molle combretaceae. Thus, the aim of this study was to evaluate cytotoxic effect of c. Pdf in traditional medical practices of ethiopia the aqueous extracts obtained from the stem bark of combretum molle r.
Chronic oral safety study of the aqueous extract of. We would like to show you a description here but the site wont allow us. The inhibition of hpgds is of importance in alleviating damage to tissues due to. Combretum molle velvet bush willow plant local names in lunyoro murama, in lusoga ndawa, in lugbarageleo,and in madiotubi where to find this plant in uganda you will typically find this tree plant located in bush land and wooded grass land all over africa common throughout uganda. Flowers of combretum molle coetzee, 2015 a, aerial parts of c. Don is an accepted name this name is the accepted name of a species in the genus combretum family combretaceae. Request pdf phytochemical analysis and antioxidant activities of combretum molle and pericopsis laxiflora in burkina faso as in several african countries, diabetes is becoming a very serious. Acetone extracts of combretum molle combretaceae on drugresistant strains of helicobacter pylori. Combretum molle, the velvet bushwillow, is a plant species in the genus combretum found in west, east and south africa the larvae of parosmodes morantii and acalyptris molleivora feed on c. Phytochemical analysis and antioxidant activities of. Hematopoietic prostaglandin d2 synthase hpgds, gst sigma is a member of the glutathione stransferase super family of enzymes that catalyses the conjugation of electrophilic substances with reduced glutathione. Antiplasmodial activities of combretum molle combretaceae. The plant leaves were washed and dried at ambient temperature under shade after collection until they were dry. The objective of this study was mainly to investigate the in vitro antibacterial activities of ethanol extracts of combretum molle r.
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